Less than 2% of the population have B negative blood. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, et al. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. After adjusting for age, sex, occupation, blood type, interval between doses of vaccination, vaccination duration, and BMI, the highest geometric mean concentration (GMC) of neutralizing antibodies was 53.1 IU/mL in the same-manufacturer vaccination group at 1530 days, which was slightly but significantly higher than the 44.6 IU/mL found in the mixed-manufacturer vaccination group (p < 0.001) (Table2; Figure2B). Patients were identified based on self-report of receiving the vaccine. Of the 107,796 individuals tested for COVID-19, 11,468 patients tested positive. N Engl J Med (2020) 383:201829. From days 31 to 240, there was a slight decrease in the GMC of neutralizing antibodies in both groups. But the virus is still in your system and you can still pass it to someone else.". This unusual clotting may cause different complications, including organ damage, heart attack and stroke. One, for instance, suggests that people with Type A may have a higher risk of catching Covid-19 and of. The retailer's cutting-edge new offering is angering some local residents. Front Neurol. Pain at the injection site, alongside redness and/or swelling Extended fatigue Headaches Widespread muscle pain Joint pain Chills Fever Nausea and vomiting According to current FDA publications,. It may affect your immune systems strength or your inflammatory response to the infection. The worst outcome of these side effects is associated with VST, why it should not be missed and treated appropriately in due time. Ackah BBB, Woo M, Stallwood L, Fazal ZA, Okpani A, Ukah UV, et al. Type B Negative. The site is secure. These include soreness where the jab was. Would you like email updates of new search results? Lancet Respir Med (2022) 10:73948. ae0fcc31ae342fd3a1346ebb1f342fcb, "An Rh status seemed protective against SARS-CoV-2 infection," the study authors wrote. Interested candidates contacted one of the study institutions directly; at this point, a personal interview was scheduled to explain the study and verify the selection criteria. There have been multiple studies on blood types and COVID-19 risk. They looked at both how likely a patient was to contract COVID-19, and how likely they were to become seriously ill (or even die) from it if they did. If these side effects occur, they should go away in a few days. 2021;8(2021):3619131. doi:10.1155/2021/3619131 Patients' mean age was 42, 77% were women, and most were white. In November 2021 in The New England Journal of Medicine, he proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects, and he called for more basic research to probe possible connections. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1107866/full#supplementary-material, 1. Four types of COVID-19 vaccine have been approved for use worldwide: mRNA, inactivated virus, adenovirus, and recombinant protein vaccines (11). doi:10.1056/NEJMoa2027187, Keywords: cellular immune response, COVID-19, inactive vaccine, kinetics, neutralizing antibody, Citation: Yuan Y, Xu J, Ma B, Chen G, Wang Z, Wang S, Jing N, Zhang J, Wang B, Yan W, Zhang Q, Zhao Q and Li Y (2023) Characteristics of humoral and cellular responses to coronavirus disease 2019 (COVID-19) inactivated vaccine in central China: A prospective, multicenter, longitudinal study. But let's back up first. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). "Up to 10 percent of people who have COVID experience side effects such as . "It's pretty clear that Type O is protective to some degree. Socio-economic status is a big vulnerability, and age and health are next in line for susceptibility. Epub 2021 May 25. In addition, a 2020 analysis in The Lancet found that compared to Covid patients who werent in intensive care, those who were critically ill in the ICU and died had higher VWF antigens in their blood. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. Post SARS-CoV-2 vaccination Guillain-Barre syndrome in 19 patients. Wong LP, Alias H, Siaw YL, Muslimin M, Lai LL, Lin Y, et al. This can result in pain, redness, or swelling at . (AC) Kinetics of interferon-gamma levels according to (A) age, (B) blood type, and (C) occupation. Nat Commun (2021) 12:1162. doi:10.1038/s41467-021-21444-5, 22. COVID-19; SARS-CoV-2; adverse reaction; neuropathy; side effect; vaccination. Zhonghua Jie He He Hu Xi Za Zhi (2021) 44:49296. The blood group types did not affect the clinical outcomes. And clotting issuesincluding strokes, kidney failure, and pulmonary embolismscome up a lot with Covid infections. There were no changes in IFN- levels and CD4 T+ lymphocyte count on days 1 to 240 (B = 0.2, 95% CI 0.03 to 0.4, p = 0.09 and B = 0.004, 95% CI 0.005 to 0.003, p = 0.105; Tables3, 4) in participants stimulated with the SARS-CoV-2 S antigen. Dynamic IgG seropositivity after rollout of CoronaVac and BNT162b2 COVID-19 vaccines in Chile: A sentinel surveillance study. O and Rh-negative blood types may already have COVID-19 antibodies. A previous study in the journal Blood Advances from 2020 also affirmed this research, adding that people with Type O blood seem to be more protected from Covid. One of the most unusual and serious side-effects of the COVID-19 vaccine jab, which has been reported from various corners is Blood clotting. Blood type doesnt affect much in our daily lives. The pituitary gland in SARS-CoV-2 infections, vaccinations, and post-COVID syndrome. The .gov means its official. Participants with blood type A had lower levels of neutralizing antibodies than those with blood type B during 114 days after vaccination (least-square mean difference = 15.8, 95% CI 11.025.2; p = 0.044) (Table S2). Factors that influence the concentration of neutralizing antibodies and cellular responses were analyzed using a multivariate linear regression model, which could be set on one of the classified variances as a reference to calculate the B value (18). There was no association with blood type and either susceptibility to COVID-19 infection or disease severity in a large cohort study, researchers said. We excluded 14 (2.4%) participants from the regression analysis and mixed model analysis due to missing data: 8 who withdrew their consent, 2 who did not answer age-related questions, 2 who missed a follow-up visit, and 2 who did not provide blood samples (Figure1). doi:10.1001/jama.2021.19499, 11. This type of side effect most commonly occurs within the first hour of when the vaccine is given and usually immediately after. 2022 Aug 15;369:577901. doi: 10.1016/j.jneuroim.2022.577901. In fact, the findings suggest that people with blood type A face a 50 percent greater risk of needing oxygen support or a ventilator should they become infected with the novel coronavirus. We constantly strive to provide you with the best information possible. Diarrhea. COVID-19 vaccine side effects can vary depending on a person's age, sex, or health. "Our next study will specifically look at such antibodies, and whether they explain the protective effect," Ray told Reuters. The results showed that those with A blood types were significantly more likely to contract the coronavirus compared with other blood types. Methods: This prospective, multicenter, observational, longitudinal study involved 595 participants with a negative SARS-CoV-2 polymerase chain reaction result who were serologically tested and followed for 8 months after vaccination. The log2-transformed level of neutralizing antibodies was used as the independent variable. It's becoming more common in people under 55. Possible side effects: Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. Opens in a new tab or window, Visit us on Instagram. Finally, individuals with certain occupations, including workers, especially older individuals and men, had low levels of antibodies and had weakened cellular immune responses following the second dose compared to their counterparts, suggesting that a longer gap between vaccine doses, which is a strategy in effect in some countries, should be re-evaluated, especially for more susceptible populations. These antibodies can also bind to and activate platelets, priming them to clump together and trigger clotting. Acta Neurol Scand. Patients were aged 25 to 63 years, had PNH granulocyte clones of 80%, and had not received transfusions in the past year. Front. Hum Vaccin Immunother. Vaccination is the most effective measure to reduce mortality from COVID-19 and serious diseases (12); however, vaccines are scarce in certain countries and some regions in China (13). Factors that influence humoral and cellular immune responses were defined within 240 days in individuals vaccinated with an inactivated Chinese vaccine. Epub 2021 Oct 31. 30. COVID-19 vaccines can cause mild side effects after the first or second dose, including: Pain, redness or swelling where the shot was given Fever Fatigue Headache Muscle pain Chills Joint pain Nausea and vomiting Swollen lymph nodes Feeling unwell Most side effects go away in a few days. Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). Published by John Wiley & Sons Ltd. The clots may also form in multiple places in the body, including in the lungs. The severity of the COVID-19 disease Recent data suggests that people with blood type A have a significantly higher risk of acquiring COVID-19 than non-A blood types. Those who are O-negative may be the least likely to get COVID. COVID19 vaccination acceptance among healthcare workers and nonhealthcare workers in China: a survey. afficher des publicits et des contenus personnaliss en fonction de vos profils de centres dintrt; mesurer lefficacit des publicits et contenus personnaliss; et. Vaccines are still important, as are smart choices to protect yourself from germs. When the researchers looked at this second classification, there was further good newspeople in any blood group which is Rh-negative are also "somewhat protected" from the virus. All participants were clinically evaluated and blood samples were collected for immunological evaluation on day 0. We dont know why people with Type O might possibly be more protectedbut there are a lot of theories. J Clin Transl Res. SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy. Vaccine induced immune thrombotic thrombocytopenia causing a severe form of cerebral venous thrombosis with high fatality rate: a case series. You've read a lot about what puts you at an increased risk of having a severe case of COVID-19, from smoking to carrying around extra weight to being over a certain age. Our product picks are editor-tested, expert-approved. Lancet (2022) 399:5219. There were no differences in the positive rate of neutralizing antibodies between the groups throughout the observation period (p = 0.891; Figure2A). METHODOLOGY A cross-sectional study was carried out, in which . Opens in a new tab or window. All studies so far have only looked at blood type in connection to symptomatic cases of coronavirus, Dr. Aronoff points out. Bookshelf The participants in the study (mixed-manufacturer vaccination for the two doses) and control (same-manufacturer vaccination for both doses) groups remained in local community health centers for at least 30min after vaccination to monitor safety, and the occurrence of any adverse event during this observation period was recorded. Most side effects are mild and normally last only a day or two. It also can be potentially quite large and thus a bit unsettling. One study of over 3,000 people who got a COVID-19 vaccine did not find any increased side effects or other issues among people with different blood types. xhr.open('POST', 'https://www.google-analytics.com/collect', true); This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. 36 COVID-19 vaccine recipients develop rare blood disorder after getting Moderna, Pfizer shots Immune thrombocytopenia is a condition that causes your platelet count to fall. We know the Covid virus damages the lining of your blood vessels. mesurer votre utilisation de nos sites et applications. doi:10.1128/spectrum.01181-21, 21. COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices. 2021 John Wiley & Sons A/S. document.addEventListener( 'DOMContentLoaded', function() { Bestlifeonline.com is part of the Meredith Health Group. 2023;47(1):5. doi: 10.1186/s42269-023-00981-7. var xhr = new XMLHttpRequest(); Expert Rev Vaccines (2021) 20:13617. The relationships between blood type-, age-, sex-, and occupation-related reactivities of neutralizing antibodies and cellular immune responses were demonstrated. Shaw AT, Bauer TM, de Marinis F, Felip E, Goto Y, Liu G, et al. INTRODUCTION The goal of this study was to evaluate the side effects of application of the Pfizer BioNTech vaccine on the workers at a Mexican hospital. *Correspondence: Yi Li, liyilebmed@henu.edu.cn, These authors have contributed equally to this work, Advancing the Understanding of Emergence of SARS-CoV-2 Genetic Variants and COVID-19 Vaccine Efficacy: Essential Clinical and Molecular Insights and Breakthroughs, View all "The smaller sample sizes and retrospective, observational nature of many prior studies, in addition to their striking heterogeneity of ABO associations with disease susceptibility and severity, could be due to chance variations, publication bias, differences in genetic background, geography and environment, and viral strains," they wrote. The study complied with the principles of the Declaration of Helsinki and Good Clinical Practice, and was approved by the Ethics Committee of Henan Provincial Peoples Hospital (approval number 20210051, date of approval May 24, 2021). The full coverage rate of the COVID-19 vaccination program has reached approximately 90% of the population required to be vaccinated in 2022 (10). Your body then releases von Willebrand factor, or VWF, into your blood so it can fix the damage to the vessel walls. The most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. The population required to be vaccinated included children aged 311 years, adolescents aged 1217 years, and adults. And guess what: People with Type A blood have higher levels of VWF naturally than people with type O blood, Dr. Udden points out. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. J Med Internet Res (2021) 23:e26089. 2023 Feb 25;28(1):102. doi: 10.1186/s40001-023-00992-0. Eur J Med Res. In contrast, people with blood type O appear to have about a 50 percent reduced risk of severe COVID-19. Wu F, Yuan Y, Deng Z, Yin D, Shen Q, Zeng J, et al. Yet these risks are relative, meaning people with type O blood are not immune to COVID-19. BNT162b2 COVID-19 vaccine and correlates of humoral immune responses and dynamics: A prospective, single-centre, longitudinal cohort study in health-care workers. The couple will likely attend the big event. However, some studies have people wondering if blood type affects coronavirus risk. The observations made in the "Study of blood group analysis and its correlation with lymphopenia in Covid- 19 infected people" were carried during the first wave of cases for two months in a retrospective manner. Opens in a new tab or window, Visit us on Twitter. They looked at patients from March 3 to Nov. 2, 2020 who were tested for SARS-CoV-2 and had a recorded blood type, comparing positive versus negative tests, hospitalized versus non-hospitalized patients and ICU versus non-ICU patients. Nous, Yahoo, faisons partie de la famille de marques Yahoo. Additional research has buttressed the possibility of a link. And for more signs you could've contracted the virus, check out If You Have This Symptom, There's an 80 Percent Chance You Have COVID. Unfolding the determinants of COVID-19 vaccine acceptance in China. 2022 Dec 22;78:100157. doi: 10.1016/j.clinsp.2022.100157. if( 'moc.enilnoefiltseb' !== location.hostname.split('').reverse().join('') ) { Table1 Baseline characteristics of the study participants (N = 595). Women and younger adults tend to have more side effects than men or older adults do. In all cases, the immune system creates antibodies that activate platelets in the bloodstream, he said. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. It is suggested that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. Post SARSCoV2 vaccination GuillainBarre syndrome in 19 patients. Blood type is actually a pretty weak player, Dr. Udden says. Associations were observed between blood type and production of neutralizing antibodies and IFN-. J Med Virol (2022) 94:411524. First there is a reaction in the arm where you are injected - think swelling and soreness - as the immune system swings into gear. YL, SW, and WY were involved in the project management and organizational work. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine in children aged 6-17 years: A preliminary report of COV006, a phase 2 single-blind, randomised, controlled trial. Vous pouvez modifier vos choix tout moment en cliquant sur le lien Tableau de bord sur la vie prive prsent sur nos sites et dans nos applications. As with all vaccines, side effects may occur after getting the COVID-19 vaccine. Domingo JL. This finding suggests that cellular immune responses lasted longer than humoral responses in the vaccinated population. That link was established pretty early on in the pandemic and scientists didn't let it go. Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). Participants with blood type A and workers had lower levels of IFN- than those with blood type B and medical staff, respectively (B = 0.16, 95% CI 0.040.28, p = 0.01 and B = 0.27, 95% CI 0.46 to 0.07, p = 0.008, respectively; Table3; Figures3B, C). A retrospective analysis of clinically confirmed long post-COVID vaccination syndrome. But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. Very common side effects in the . There's no known connection between blood types and side effects from COVID-19 vaccines. Neurological side effects occur with any of the approved vaccines but VST particularly occurs after vaccination with vector-based vaccines. Discussion: Two doses of the Chinese inactivated vaccine induced robust and rapid antibody expression and cellular immune responses. } else { If You Have One of These Blood Types, You May Be Safe From COVID, It Only Takes This Long to Get COVID in a Room With Someone Who Has It, These 2 Places Could Be Closing Soon, White House Official Warns, How Likely You Are to Catch COVID in the Next Month, Expert Says, If You Have This Symptom, There's an 80 Percent Chance You Have COVID, tracked the blood types of nearly 2,200 COVID-19 patients, A blood types were significantly more likely. doi:10.1016/j.jclinepi.2021.12.015, 4. Patients with type O and rhesus negative (Rh-) blood groups may have a lower risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe coronavirus disease 2019 (COVID-19) illness, according to a study published in the Annals of Internal Medicine. Serious side effects. doi:10.1016/j.vaccine.2020.12.083, 6. Yin F, Wu Z, Xia X, Ji M, Wang Y, Hu Z. Patient characteristics and reactions to the COVID-19 vaccines are shown in Table 1. The clots can clog up important . Reactogenicity analysis results are presented as percentage of participants. 1 The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. The mixed model distribution curves of log2-transformed neutralizing antibodies and log10-transformed cellular response with duration adjusted by age, sex, BMI, occupation, vaccination mode, duration since the second dose, interval between doses of vaccination, and ABO blood type were plotted using Prism 8.0 (GraphPad Software Inc., USA). The https:// ensures that you are connecting to the doi: 10.6061/clinics/2021/e3286. A linear regression analysis using a mixed-effect model showed that age, vaccination mode, occupation, interval between doses of vaccination, and vaccination duration were factors significantly associated with the levels of neutralizing antibodies (Tables13; Tables S1S7). The profile of solicited adverse events in this study was consistent with that of a previous study (20). 2022 Dec 6;10(34):12617-12622. doi: 10.12998/wjcc.v10.i34.12617. Clinics (Sao Paulo). The virus can lead to pneumonia, respiratory failure, heart problems, liver problems, septic shock, and death. Accessibility The new study's co-author, Joel Ray, MD, of St. Michael's Hospital, suggested that people with these more resistant blood types may have already developed antibodies that can recognize certain aspects of the novel coronavirus and are therefore better prepared to fight it off. "There's a fairly decent amount of existing literature beyond SARS-CoV-2" that certain blood types can play a role in disease risk and severity, says Joel Ray, M.D., a clinician scientist and professor at St. Michael's . To date, coronavirus disease 2019 (COVID-19), a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected over 600 million people worldwide and killed over 6 million people (1, 2). Healthcare professionals, particularly neurologists involved in the management of patients having undergone SARS-CoV-2 vaccinations, should be aware of these side effects and should stay vigilant to recognize them early and treat them adequately. Whether mild or severe, data from the U.S. Centers for Disease Control and Prevention (CDC), has shown that women are bearing the brunt of vaccine reactions, and experts believe it may be due to . 2022 Nov 9;8(6):506-508. eCollection 2022 Dec 29. It usually occurs soon after vaccination, and can be treated with epinephrine (as in an EpiPen). Common side effects include fatigue and headache. All authors contributed to the article and approved the submitted version.
